澳门威斯尼斯人所有网址

刘平副教授、孙培培教授课题组在ORGANIC LETTERS发表研究论文

时间:2020-09-26 来源:澳门威斯尼斯人所有网址 点击数:

Selective C-5 Oxidative Radical Silylation of Imidazopyridines Promoted by Lewis Acid
Li, YF (Li, Yifan)[ 1 ] ; Shu, KC (Shu, Kaichen)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*(刘平); Sun, PP (Sun, Peipei)[ 1 ]*(孙培培)


[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Peoples R China


ORGANIC LETTERS,202008,22(16),6304-6307


An oxidative cross dehydrogenative coupling of imidazopyridines with silanes was developed using di-tert-butyl peroxide as the oxidant. The coordination effect of Lewis acid was the dominant factor controlling the regioselective addition of silyl radical to imidazopyridines, and the corresponding C-5 silylated imidazo[1,2-a]pyridines were obtained in moderate to high yields with a broad substrate scope.

文章链接:
https://pubs.acs.org/doi/10.1021/acs.orglett.0c02131

Copyright © 2009-2020 澳门威斯尼斯人所有网址. All rights reserved.