Selective C-5 Oxidative Radical Silylation of Imidazopyridines Promoted by Lewis Acid
Li, YF (Li, Yifan)[ 1 ] ; Shu, KC (Shu, Kaichen)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*（刘平）; Sun, PP (Sun, Peipei)[ 1 ]*（孙培培）
[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Peoples R China
An oxidative cross dehydrogenative coupling of imidazopyridines with silanes was developed using di-tert-butyl peroxide as the oxidant. The coordination effect of Lewis acid was the dominant factor controlling the regioselective addition of silyl radical to imidazopyridines, and the corresponding C-5 silylated imidazo[1,2-a]pyridines were obtained in moderate to high yields with a broad substrate scope.